3rd Annual Symposium

HTRF^® in Drug Discovery

Sonoma, CA, USA     September 26th-28th, 2007

A unique opportunity to network with HTRF^® users and discuss the latest screening methods.

Pre-Program

Registration
4:00 pm - 5:00 pm

Conference opening & keynote addresses
5:00 pm - 7:00 pm

• Welcome address
• All roads to successful drug discovery lead through cell-based assays (and why shouldn't they?) - R. Garippa, Hoffmann-La Roche
• Progress towards a generic intracellular S/T-kinase assay platform - A Brinker, GNF

Wine Reception - 7:00 pm

Poolside reception with French and Californian wine tasting

Session 1: Kinase screening & profiling
9:00 am - 12:35 pm

Kinome screening, profiling and mechanistic studies using HTRF^® toolbox reagents and the universal HTRF^® KinEASE™ platform.

Session Chair: Ulf Bömer, Bayer Schering, Germany

• Schering AG's platform for miniaturised kinase assays - U. Bömer, Bayer Schering
• Characterization of the HTRF^® assay for a truncated human target of rapamycin (mTOR) kinase - J. Pai, Schering-Plough
• Application of TR-FRET Systems in Kinome Profiling, Mechanistic Studies, and as an Alternative to Conventional Fluorescence Polarization - E. Johnson, Abbott
• Case Studies of uHTS compatible Detection Formats for Kinase Assays - T. Spicer, Scripps
• Large Scale Kinase Profiling: Kinomics Analysis with HTRF Technology - Jeff Till, Millipore

Lunch break

Session 3: Kinase roundtable
5:30 pm - 6:30 pm

Wine Tasting & Dinner - 7:00 pm

At Sebastiani Vineyards & Winery

Session 2: HTRF^® as an alternative to conventional technologies - 2:00 pm - 5:00 pm

Adaption of conventional assay formats to HTRF^® and exciting new applications of HTRF^® technology. Case studies on biomarkers, bioprocesses and screening of natural compounds.

Session Chair: Wei Zheng, NIH Roadmap, USA

• The use of HTRF^® in an automated workflow for Human MAb screening at Medarex - D. Williams, Medarex
• Comparison of two HTRF^® assays for high throughput screening of a natural product library - M. Jobling, Eskitis Institute, Griffth University
• qHTS for identifying the cell-membrane permeable inositol monophosphatase inhibitors with HTRF^® IP-One reagents - W. Zheng, NIH
• Development of an IL5 HTRF^® assay for high throughput screening of primary human T cells - J. Brogdon, Novartis
• Development of an HTRF^® antibody screening assay for cell line development - E. Idusogie, OncoMed

Session 4: GPCRs as drug targets
9:00 am - 12:35 pm

A session dedicated to cell-based GPCR screening including cAMP uHTS, exploration of IP-One applications as well as new data on homogeneous detection of receptor heterodimerization.

Session Chair: Marcie Glicksman, Harvard Medical School, USA

• Results from high throughput screening the GPCR, GPR-54, with the IP-One assay - M. Glicksman, Harvard Medical School
• HTRF^® cAMP assays: discussion of best practices for assay design and data analysis - N. Burford, Bristol Myers-Squibb
• Use of the IP-one HTRF^® assay for HTS and secondary screening of Gq and Gα16 coupled receptor targets - R. Bouhelal, Novartis
• HTRF^® and snap-tag technology for high throughput analysis of protein: protein interaction at the surface of living cell - J.-P. Pin, IGF
• Ultra high throughput GPCR screening utilizing CCD imaging systems with HTRF^® - S. Feighner, Merck

Lunch Break

Session 5: Study of the ubiquitination pathway
2:00 pm - 4:00 pm

A session dedicated to understanding ubiquitination as a drug target and screening applications.

• Inhibitors of Ubiquitin-Specific Proteases, the other side of the mountain - J.-C. Rain, Hybrigenics
• Novel HTRF^® Assays for Ubiquitin Ligase Drug Discovery - H. Barr, Proteologics

Session 6: GPCR roundtable
4:30 pm - 5:30 pm

Conference closure

Golf Outing

The StoneTree Golf Course

18 holes of golf - 9:00am

Location:

The Lodge at Sonoma Resort & Spa

The Lodge at Sonoma Resort & Spa is nestled in beautiful Sonoma Valley. Merging contemporary facilities with the gracious spirit of California's beloved wine country, the Lodge provides a revitalizing retreat while discovering the many delights of Sonoma County and the San Francisco Bay Area. With the convenience of being only blocks away from the historic Sonoma Plaza, guests enjoy a vast array of incredible restaurants, enticing shops, and entertaining activities within walking distance.

Registration Information:

Registration is required to attend the HTRF Symposium. Space is limited to 150 participants. Packages include conference passes and hotel accommodations at The Loge at Sonoma Resort & Spa.

2 Night and 3 Night Packages: include lodging, breakfasts, lunches and coffee breaks, passes to attend all scientific sessions, as well as passes for all associated social events during your stay such as wine receptions and vineyard dining.

2 night package $700
3 night package $1000

Conference Day Pass: available for $100 which includes admission to that day's scientific sessions as well as coffee breaks and lunch. Pre-registration for day passes is required due to space limitations.

Online Registration