Tag-lite® cell lines

A unique multi-mode cellular platform to address the GPCR signaling network
This comprehensive cellular platform addresses the entire GPCR signaling network. Tag-lite cell lines are optimized to be combined with a portfolio of kits and reagents in highly selective ligand binding and receptor dimerization assays. This rapid and non-radioactive platform has been designed for a comprehensive investigation of receptor network signaling, while preserving the functionality of the receptor and the intracellular signaling pathways.
All the cell lines have been validated with HTRF® kits and reagents for ligand binding assay and at least 2 functional assays including cAMP, IP-One, phospho-Erk and internalization assays.
Features:
- SNAP-GPCR stable cell lines
- Single technology and cellular platform compatible with all GPCR classes and families
Applications:
- Ligand binding assays
- Second messenger accumulation assays with cAMP kits or IP-One kits
- Phospho-Erk assays
- Tag-lite internalization assays
| Family | Target | Part # | Binding assay |
Functionnal assays | Product insert | MSDS | ||
|---|---|---|---|---|---|---|---|---|
| cAMP or IP-One | ERK | Internalization | ||||||
| Adrenoceptor | Beta2 | C1SU1BETA2 | ![]() |
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| Chemokine | CCR1 | C1SU1CCR1 | ![]() |
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| CCR5 | C1SU1CCR5 | ![]() |
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| CXCR4 | C1SU1CXCR4 | ![]() |
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| CXCR7 | C1SU1CXCR7 | ![]() |
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| Cholecystokinin | CCK1 | C2SU1CCK1 | ![]() |
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| CCK2 | C1SU1CCK2 | ![]() |
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| Dopamine | D2 | C2SU1D2 | ![]() |
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| EGFR | EGFR | C1SU1EGRF1 | ![]() |
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| Endothelin | ETB | C1PU1ETB | ![]() |
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| Ghrelin | GHSR1 A | C1SU1GHSR1A | ![]() |
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| Melanocortin | MC4 | C1SU1MC4 | ![]() |
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| Opioid | Delta opioid | C2SU1DOP | ![]() |
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| Mu opioid | C2SU1MOP | ![]() |
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| Tachykinin | NK1 | C1SU1NK1 | ![]() |
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| Vasoactive Intestinal Peptide | VPAC1 | C2SU1VPAC1 | ![]() |
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| Vasopressin/Oxytocin | V1a | C1PU1V1A | ![]() |
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| V2 | C1PU1V2 | ![]() |
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