GPCRs - Comprehensive HTRF® cellular platform
- Cellul’erk kit, Erk1/2 phosphorylation assay
- cAMP kits, a line of ready-to-use assays kits
- IP-One Tb, the unique Gq second messenger assay
- Tag-lite®, homogeneous and non-radioactive ligand binding assays
- Phospho-AKT (Ser473)
& Phospho-AKT (Thr308) kits
Ligand binding assays
Functional assays
Downstream phenotypic
assays
Companion products
Kits and reagents to address the whole GPCR activation pathway
Cisbio Bioassays has supported GPCR investigation for many years regularly creating cutting edge assays and technologies suited to receptor characterization, compound screening and lead optimization.- Homogeneous and non-radioactive ligand binding assays with Tag-lite® technology.
- Unique and comprehensive GPCR second messenger assay platforms with cAMP and IP-One accumulation assays.
- Downstream phenotypic assays.
Literature highlights
Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
New sensor technology to study mGluR activation and conformational change in living cells using Tag-lite substrates and IP-One (by IGF and Cisbio bioassays).
The combination of Tag-lite and cAMP assays to probe peptide conjugate ligand binding (by Max Planck Institute)
cAMP, cell-based kinase, internalization assays to demonstrate biased and pathway selective ligands (by Actelion).